Although there are diagnostic and prognostic molecular tests for ACC such as the IGF-2, Ki-67, p53, BUB1B, PBK, HURP, NEK2, DAX, Wnt/β-catenin and PI3K signaling pathways, they remain largely unutilized in morphologic assessment coupled with ancillary diagnostic and prognostic modeling of ACC (Mete et al., 2018). Here, BUB1B is linked to adrenal cortex carcinoma.