IGF2 and adrenal cortex carcinoma: Although there are diagnostic and prognostic molecular tests for ACC such as the IGF-2, Ki-67, p53, BUB1B, PBK, HURP, NEK2, DAX, Wnt/β-catenin and PI3K signaling pathways, they remain largely unutilized in morphologic assessment coupled with ancillary diagnostic and prognostic modeling of ACC (Mete et al., 2018).