For example, the most frequent alterations observed in ACC are overexpression of insulin-like growth factor 2 (IGF-2) (Gicquel et al., 2001; Giordano et al., 2003; de Fraipont et al., 2005) and constitutive activation of the Wnt/β-Catenin pathway (Gaujoux et al., 2011). Here, IGF2 is linked to adrenal cortex carcinoma.