In addition, Chen et al. and Zhan et al. demonstrated that PRC1 contributes to tumorigenesis by regulating the Wnt/β-catenin signaling pathway in a positive feedback loop (Chen et al., 2016; Zhan et al., 2017), in which carcinogenesis and progression may feasibly be mediated in ACC. This evidence concerns the gene PRC1 and adrenal cortex carcinoma.