The methylation levels were positively related to O-6-methylguanine-DNA methyltransferase (MGMT) promoter unmethylation but were negatively associated with TP53 mutant, α-thalassemia mental retardation X-linked (ATRX) mutant, and co-deletion of 1p/19q in Cluster3 (Supplementary Table 4). Here, MGMT is linked to thalassemia.