In several chronic inflammatory diseases, GILZ expression inversely correlates with disease severity, suggesting that lower levels may aggravate these diseases and/or may be part of the pathogenesis [reviewed in (25, 28)] For instance, GILZ expression negatively correlates with disease severity in lupus patients, and murine models of this disease (29, 30). This evidence concerns the gene TSC22D3 and systemic lupus erythematosus.