NOS2 and coccidioidomycosis: Additionally, studies conducted by Gonzalez et al. showed that mice deficient in NADPH oxidase (NOX2) were more susceptible to infection with C. posadasii compared to wild type mice while inducible nitric oxide synthase (iNOS) knock-out mice demonstrated that iNOS does not play a significant role in the control of Coccidioides infection (25, 26).