SLC2A1 and obesity due to melanocortin 4 receptor deficiency: In support of this idea, the short- and long-term effects of obesity on NK cell metabolism are known to differ: in a pediatric cohort, obesity was associated with increased Glut1 and pS6 expression (9), whereas in adults, obesity was associated with decreased 2-NBDG uptake (a proxy for glucose uptake) and pS6 expression (10).