For example, several clinical trials are currently evaluating combined VEGF/VEGFR and PD-1/PD-L1 inhibitors for various cancer types including renal cell carcinoma, recurrent glioblastoma, ovarian cancer and colorectal cancer (NCT03024437, NCT02659384, NCT02873962, NCT02017717). This evidence concerns the gene KDR and hereditary clear cell renal cell carcinoma.