We have originally raised the importance of changes in SP-D expression in resolving allergen and O3-induced airway inflammation (26) by demonstrating that a differential ability of Balb/c and C57BL/6 mice to respond to allergen (27) or O3 (28), was inversely associated with the amount of SP-D recovered from the airways of these mouse strains (28, 29). The gene discussed is SFTPD; the disease is inflammation.