These results are supported by studies of Baek et al. (65), who adoptively transferred CD4+CD25+ Treg into 3xTg-AD mice and observed improved cognitive function, reduced deposition of Aβ plaques, decreased microglial activation, and decreased production of pro-inflammatory cytokines such as IL-6, IFN-γ, or IL-17. This evidence concerns the gene CD4 and Alzheimer disease.