When analyzing each ACR criterion separately we found that patients with >3 anti-KIR autoantibodies had an increased risk of fulfilling the criteria for nephritis (80.0 vs. 27.2%, p = 0.001) and immunologic disorder (100 vs. 63.3%, p = 0.02) compared to patients with no anti-KIR autoantibodies (Figure 5A). The gene discussed is KIR3DL1; the disease is nephritis.