The frequency of Tbet-expressing Tregs but not ConvT cells increased by day 6 as compared to untreated mice when only mild signs of colitis were observed (Figures 3C,D) prompting us to hypothesize that Th1-like Tregs might represent a “ready-to-use” source of IFNγ supporting the early stage of Th1-mediated immune response. This evidence concerns the gene IFNG and colitis.