IPEX syndrome is a rare x-linked recessive monogenic autoimmune disorder resulting from a mutation in the gene FOXP3. Patients present with eczematous dermatitis, enteropathy, and an endocrinopathy (usually diabetes mellitus or hypothyroidism) (50). This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.