ZBP1 and infection: Several previous studies have reported increased virus titers and disease severity in ZBP1−/− mice after infection with influenza virus (Kuriakose et al., 2016; Thapa et al., 2016), HSV-1 (Guo et al., 2018), and MCMV (Upton et al., 2012; Sridharan et al., 2017).