A recent study by Jorgensen et al. (2018) reported that a serve influenza patient with defective RIG-I exhibited decreased antiviral responses as well as increased pro-inflammatory responses, which not only demonstrated that RIG-I played a critical role in host cellular responses to human IAV, but also supported that cooperation of host cellular antiviral responses and inflammatory responses was crucial for the pathogenesis of IAV. This evidence concerns the gene RIGI and influenza.