To directly address this possibility, we investigated the impact of NMDAR-Ab from one patient with schizophrenia on D1R that were genetically prevented to interact with GluN1-NMDAR (D1RΔt2-CFP): the intracellular t2 segment is a major binding sequence to the GluN1 subunit (17) (Figure 1D, left). Here, GRIN1 is linked to schizophrenia.