The present study indicates that the change in Cx43 expression is consistent with the improvement of NDS and the decrease in the cerebral infarction area, suggesting that the monotherapy and combination therapy of Ginseng and Rhubarb have a neuroprotective effect via the down-regulation of Cx43; while the combined use of Ginseng and Rhubarb could play a better protective role. Here, GJA1 is linked to cerebral infarction.