AGPAT1 and neurodegenerative disease: In AD pathological condition, the increased lysophospholipid acyltransferase activity and decreased phospholipase A2 activity would decrease LPC level (Ross et al., 1998), further lead to the rapid production and accumulation of free fatty acids and lipid peroxides, eventually result in CNS inflammation, oxidative stress, and neurodegenerative diseases (Farooqui et al., 2000).