For instance, the formation of heterodimers between TAAR1 and the dopamine receptor 2 (D2R) has been observed (Espinoza et al., 2011; Harmeier et al., 2015) and allegedly leads to recruitment of β-arrestin 2 and silencing of the GSK3β (Harmeier et al., 2015), a pathway known to be involved in psychosis and mood disorders (Willi and Schwab, 2013) and targeted by lithium treatment (Muneer, 2017). This evidence concerns the gene TAAR1 and psychotic disorder.