AGO2 and neoplasm: PARN may also participate in miRNA-mediated deadenylation due to association with Ago2 in the RNA-induced silencing complex (RISC), and promote degradation of the oncogenic miR-21 followed by restoration of tumor suppressor activity of corresponding protein targets such as PTEN and p53 (Boele et al., 2014; Zhang et al., 2015a).