The Makarov and Ilinskaya groups studied the cytotoxicity of binase using a number of cell lines, distinguished by expressed oncogenes: myeloid precursors FDC-P1; FDC-P1-N822K cells expressing the KIT oncogene; transduced FDC-P1 cells expressing the AML1-ETO oncogene; transduced FDC-P1-N822K cells expressing the AML1-ETO and KIT oncogenes; cells of acute myeloid leukemia Kasumi-1, also expressing both oncogenes, and human ovarian cancer cells (Ilinskaya et al., 2007; Mitkevich et al., 2011; Garipov et al., 2014; Table 4). Here, KIT is linked to acute myeloid leukemia.