Dicer, an important RNase III endonuclease involved in miRNA processing, is down-regulated in many tumours, such as neuroblastoma (Lin et al., 2010), endometrial cancer (Torres et al., 2011), nasopharyngeal carcinoma (Guo et al., 2012), gallbladder adenocarcinoma (Shu et al., 2012), transitional cell carcinoma of the urinary bladder (Wu et al., 2012), breast cancer (Khoshnaw et al., 2012), lung cancer (Karube et al., 2005), gastric cancer (Zheng et al., 2007), colorectal cancer (Sun et al., 2017), and ovarian cancer (Pampalakis et al., 2010; Table 3). Here, DROSHA is linked to neoplasm.