Attempts to find molecular targets of RNase A in the tumour and blood of tumour-bearing mice (with the example of Lewis lung carcinoma) revealed that antitumor and antimetastatic action of RNase A is realized via degradation of extracellular circulating miRNAs and is accompanied by significant boost of miRNA synthesis in tumour tissue (Mironova et al., 2013b). The gene discussed is RNASE1; the disease is Carcinoma, Lewis Lung.