For patients with malignant melanoma, the presence in blood of mRNA encoding for tyrosinase, MAGE-3 (melanoma-associated antigen 3), MCAM (melanoma cell adhesion molecule), p97 (transitional endoplasmic reticulum ATPase) and HMBS (hydroxymethylbilane synthase) is typical (Hoon et al., 2000; Hasselmann et al., 2001). This evidence concerns the gene HMBS and melanoma.