miR-21 represents one of the first microRNAs being defined as an oncomir, that regulate multiple tumour suppressors like the PTEN (phosphatase and tensin homolog), PDCD (programmed cell death), p53 (tumor suppressor p53) and TP63 (tumor protein p63) pathways (Meng et al., 2007; Asangani et al., 2008; Papagiannakopoulos et al., 2008). The gene discussed is TP63; the disease is neoplasm.