APEX1 and neoplasm: Of great interest are accumulating evidences demonstrating that APE1 may be involved in the control of gene expression due to its unsuspected activities during RNA metabolism (Antoniali et al., 2014; Jobert and Nilsen, 2014; Vohhodina et al., 2016) including miRNA expression (Antoniali et al., 2017b), thus enhancing APE1’s critical functions in tumour progression.