Insulin supplied intranasally in subjects presenting amnestic mild cognitive disorder or AD has been reported to have cognitive benefits (Jochum et al., 2004), (Musiek and Holtzman, 2015), and thus, this opened the way to a new clinical trial: the Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF, NCT01767909). Here, INS is linked to Alzheimer disease.