MAPT and Parkinson disease: Moreover, the direct relation of tau and α-syn in these diseases is supported by: (i) hyperphosphorylation of tau as consequence of α-syn effect in the mice model for PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Duka et al., 2006), (ii) α-syn and p-tau presence in NFT and LBs (Shao et al., 2006); (iii) the proteasome promotes the oxidation of α-syn, which in turn triggers recruitment of tau inside oligodendroglial cells in synucleinopathies (Riedel et al., 2009).