The involvement of microglia in AD pathogenesis was studied in the light of the Aβ (Guillot-Sestier et al., 2015; Heneka et al., 2015) and also in the context of tau oligomerization (Maccioni et al., 2009; Morales et al., 2010; Maccioni, 2012; Morales et al., 2014). Here, MAPT is linked to Alzheimer disease.