Moreover, studies conducted in transgenic mouse with mutation of human tau associated with FTD model reported microgliosis and synaptic disruption, prior to formation of NFT in the hippocampus, suggesting that inflammatory response can carry over to the formation of NFT in FTD (Yoshiyama et al., 2007), in accordance with our theory of neuroimmunomodulation (Fernandez et al., 2008; Rojo et al., 2008; Maccioni et al., 2009). Here, MAPT is linked to frontotemporal dementia.