AKT1 and neoplasm: Interleukin 6 has also been shown to play key functions in multidrug resistance via JAK, STAT3, PI3K/Akt, and Ras-MAPK signal pathways (Ghandadi and Sahebkar, 2016; Zang et al., 2017), tumor cell migration (Che et al., 2019), invasion (Cao et al., 2017), and other pathways of carcinogenesis.