Compared with the control mice, the mice with STZ-induced T1DM showed significant suppression of PI3K/AKT signaling in the hypertrophic heart, where phosphorylation of PI3K, PDK1, and AKT was significantly reduced and that of PTEN was significantly increased (Figures 6A, B, P < 0.05). This evidence concerns the gene PTEN and type 1 diabetes mellitus.