PDK1 and type 1 diabetes mellitus: In addition, we showed that the PI3K/AKT signaling pathway is impaired in the heart of both mice with T1DM and T2DM; however, administration of carvacrol could restore the PI3K/AKT signaling pathway by increasing the levels of phosphorylated PI3K, PDK1, and AKT and reducing PTEN phosphorylation.