Our results indicate carvacrol significantly activates PI3K/AKT signaling in both T1DM and T2DM by increasing the phosphorylation of PI3K, AKT, PDK1, and AS160; reducing the phosphorylation of PTEN; and subsequently facilitating GLUT4 membrane translocation (Figure 9). This evidence concerns the gene TBC1D4 and type 1 diabetes mellitus.