Our results indicate carvacrol significantly activates PI3K/AKT signaling in both T1DM and T2DM by increasing the phosphorylation of PI3K, AKT, PDK1, and AS160; reducing the phosphorylation of PTEN; and subsequently facilitating GLUT4 membrane translocation (Figure 9). The gene discussed is TBC1D4; the disease is type 2 diabetes mellitus.