In summary, our study demonstrated that carvacrol protects against T1DM- and T2DM-induced cardiac remodeling and improves left ventricular function, potentially through promotion of PI3K/AKT signaling-mediated GLUT4 translocation to the plasma membrane that enhances glucose uptake by cardiomyocytes. Here, SLC2A4 is linked to type 1 diabetes mellitus.