HDC and tuberous sclerosis: With the exploitation of metabolite-related proteins and researching the literature (Schroeder and Adams, 1941; Masserano and Weiner, 1983; Yoshimura et al., 1987; Ito et al., 2000; Burkhard et al., 2001; Kwok et al., 2002; Whitfield et al., 2002; Nakanishi et al., 2004; Han et al., 2010; Kimura, 2011; Caplin et al., 2012; Congo Carbajosa et al., 2015), finally 10 proteins (TH, CBS, DDC, CTH, TYR, HDC, PLD2, AGXT2, KAT, ALT) considered as potential markers of TSC on SHR rats were preliminarily confirmed.