The bars were colored with gradient color from deep blue (smaller P value) to sea blue (bigger P value), which represented the following: function 1, platelet activation; function 2, vascular smooth muscle contraction; function 3, protein processing in endoplasmic reticulum (P < 0.01); function 4, pathways in cancer; function 5, African trypanosomiasis; function 6, endocrine and other factor-regulated calcium reabsorption; function 7, long-term depression; function 8, long-term potentiation; function 9, renin secretion; and function 10: inositol phosphate metabolism (P < 0.05). Here, REN is linked to human African trypanosomiasis.