REN and cancer: They were classified into 10 functional categories as follows: platelet activation, vascular smooth muscle contraction, protein processing in endoplasmic reticulum (all P < 0.01), pathways in cancer, African trypanosomiasis, endocrine and other factor-regulated calcium reabsorption, long-term depression, long-term potentiation, renin secretion, and inositol phosphate metabolism (all P < 0.05) (Figure 3).