Therefore, the objective of the current study was to determine whether interactions with H3Rs mediate in vivo gastroprotection applying the acidified ethanol-induced gastric ulcers and gastric acid secretion model in C57BL/6 mice, and following intragastric (i.g.)administration of the potent and selective H3R antagonist/inverse agonist M39 in presence and absence of the selective and potent H3R agonist RAMH (Figure 1). The gene discussed is HRH3; the disease is gastric ulcer.