As expected from our previous comparison of PSP patients against healthy controls (Brendel et al., 2017), a significantly higher [18F]-THK5351 uptake in the midbrain of PSP patients compared to all other patient groups was observed, a region that is known to be affected by both increased MAO-B levels (Tong et al., 2017) and tau pathology (Dickson et al., 2010) in PSP. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.