Recently, RuvB-like 2 (RUVBL2) was found to interact with catenin beta 1 (CTNNB1), telomerase reverse transcriptase (TERT), MYC proto-oncogene (MYC), nuclear factor-kappa B1 (NFKB1), etc. to regulate the cancer-related signaling pathways in HCC. Here, RUVBL2 is linked to cancer.