NRP1 and familial pancreatic carcinoma: The level of NRP-1 expression was significantly correlated with tumor grade (P = 0.015), lymph metastasis (P = 0.002) and AJCC staging (P = 0.044), and marginally (P = 0.087) correlated with serum levels of carbohydrate antigen (CA) 19-9, a well-accepted blood-based biomarker for pancreatic cancer [25], but not with patients’ gender and age, tumor location or size (Table 1).