Hence, this review focused on the CD146+ expression T cells (or lymphocytes), apoptosis of T cells and lung cancer, binding partners of CD146+ , molecular signaling of CD146+, CD146+ a novel marker of lymphocytes subset population, immunophenotyping and detection of CD146+, CD146+ T cells in cancer and effects of methanol extract of Calotropis procera leaf on CD146 expression. The gene discussed is MCAM; the disease is cancer.