RAC1 and neoplasm: Univariate analysis showed that TUFT1 expression was positively correlated with tumor size, histological grade, axillary lymph node metastasis, and Rab5-GTP and Rac1-GTP expression (p = 0.024, p = 0.009, p = 0.000, p = 0.000, and p = 0.029, respectively; Table 1).