Because TUFT1 can promote proliferation and metastasis and inhibit apoptosis in MDA-MB-231 cells [8, 11], to evaluate whether TUFT1 expression directly contributes to chemotherapy resistance in TNBC, we used MDA-MB-231-shTUFT1 cells and control MDA-MB-231 cells to generate a xenograft tumor model. Here, TUFT1 is linked to neoplasm.