To find the direct target molecular responsible for the phosphorylation of IKK-β in PLA treated cervical cancer cells, we selected HeLa and C-33A cells and investigated several signals which were reported to modulate the biological behavior of cells, including PKA, ERK1/2, PI3K/Akt, and PKC, by using their specific inhibitors. The gene discussed is IKBKB; the disease is cervical cancer.