Upregulation of mRNA encoding for the early growth response proteins (EGR1, EGR2) was previously reported in mouse cortex in response to stress52 or weaning53 and down‐regulation in response to metamphetamine abuse.37 Lozeva et al9 reported increased histamine levels in postmortem cortex of HE patients and increased occupancy of H3R. This evidence concerns the gene EGR1 and hereditary elliptocytosis.