The endogenous LanCL1 expression is upregulated at late presymptomatic stage (P75) in the spinal cord of ALS mice, which suggests a protective or compensatory function in the time frame prior to protein oxidation, neuroinflammatory acceleration, and MN death, as proposed by Chung CH et al. [27]. The gene discussed is LANCL1; the disease is amyotrophic lateral sclerosis.