To explore the role of TXNDC12 in HCC progression, we examined the expression levels of TXNDC12 in one human normal hepatocyte cell line, THLE-2, and four human HCC cell lines, Hep3B, Huh7, PLC/PRF/5, and HCCLM3. This evidence concerns the gene TXNDC12 and hepatocellular carcinoma.