However, since the dissociation of cell–cell adhesion between keratinocytes can be induced solely by deposition of anti-Dsg3 Ab to keratinocytes without contribution of immune cells31, we think that in our passive murine pemphigus model, we could evaluate the direct effect of Abl family tyrosine kinases on IgG kinetics. The gene discussed is ABL1; the disease is pemphigus.