BLOC1S2 and Varicose veins: In the NZ cohort there was a significant difference between those with either self-declared varicose veins or varicose veins with or without edema (CEAP C3 or C2 respectively) and those with CEAP ≥ C4 (Fig. 1, C-allele frequency 0.35 versus 0.40 respectively, P = 0.02).