CYP21A2 and congenital adrenal hyperplasia: Patients with CAH present a natural mutation in one of the enzymes involved in cortisol synthesis, more frequently in Cyp21A2 referred also as 21-hydroxilase (classical CAH) analogous to Cyp21a1 in rodents, which leads to impaired cortisol and adrenalin production, larger adrenal size and less vulnerability to psychological stress40.