We further analyzed the mutations of PTPRT in 10,000 metastatic cancers published by MSK-impact in 201728.It was found that PTPRT has a considerable mutation frequency in many metastatic cancers, such as melanoma, small cell lung cancer, head and neck carcinoma, suggesting that PTPRT may be involved in multiple cancers (Fig. 2C). The gene discussed is PTPRT; the disease is melanoma.