TRIM71 and Familial prostate cancer: The downregulation of mtp53 target genes by TRIM71 was also verified in primary cancers harboring mtp53s, as a significant inverse correlation between the expression of TRIM71 and mtp53 target genes was found in ovarian cancer, but not in the prostate cancers with less TP53 mutations (Fig. 4c–j, S1–S3).