The downregulation of mtp53 target genes by TRIM71 was also verified in primary cancers harboring mtp53s, as a significant inverse correlation between the expression of TRIM71 and mtp53 target genes was found in ovarian cancer, but not in the prostate cancers with less TP53 mutations (Fig. 4c–j, S1–S3). Here, TP53 is linked to Familial prostate cancer.