TP53 and cancer: We also verified the endogenous TRIM71–mtp53 interactions in various cancer cell lines, including the ovarian cancer cell lines, ES-2 (p53-S241F), TOV112D (p53-R175H), OVCA420 (p53-R273H), and OVCA433 (wtp53), the breast cancer cell line MDA-MB-468 (p53-R273H), and the colon cancer cell line HT-29 (p53-R273H) (Fig. 1d–i).