TDP2 and cancer: As expected, stable overexpression of TRIM71 did not affect mRNA expression of mtp53s in ES-2 and OVCA420 cell lines, but globally prohibited the expression of their target genes involved in different GOFs, such as c-MYC, CXCL1, MAP2K3, and NFKB2 required for cancer cell growth and survival, MMP3, MMP13, and ITGA6 for EMT and metastasis, RANGAP1 and ARHGDIA for GTP metabolism and glycolysis, and TDP2 for chemoresistance (Fig. 4a, b).