Therefore, Spearman’s correlation analysis with TCGA datasets was performed, which showed the expression of β-catenin to be positively correlated with both ETS1 and TGM2, indicating regulatory functions of ETS1 and TGM2 in β-catenin overexpression in CRC (Supplementary Fig. 2E). The gene discussed is TGM2; the disease is colorectal carcinoma.