We chose two mouse hypertriglyceridemia models to mimic different hypertriglyceridemia subtypes in this study, including glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 knockout (Gpihbp1−/−) and apolipoprotein C3 transgenic (ApoC3-tg) mice. The gene discussed is GPIHBP1; the disease is hypertriglyceridemia.