In this study, two kinds of hypertriglyceridemia mouse models allowed us to compare the effects of different kinds of TRLs on the exacerbation of acute pancreatitis, and the large areas of pancreatic necrosis induced by 10 caerulein injections in Gpihbp1−/− mice allowed us to examine the special effects of large TRL particles almost at a glance. This evidence concerns the gene GPIHBP1 and hypertriglyceridemia.