KCNMA1 and osteosarcoma: Emerging evidence indicate that the BK channels in osteoblasts may act as mechanosensors to transduce extracellular mechanical signals into cell; Davidson et al. was the first to report activation of BK channels in human G292 osteoblast-like osteosarcoma cells by the membrane stretch;19,25 in human ondonosteoblasts, BK channels also exhibit mechanosensitivity26.