Recently, one of the subtypes of potassium (K+) channels, the big conductance calcium-activated potassium channel (BK, also named Maxi K or KCa1.1), has gained considerable interest in bone remodeling6, as global deletion of BK channels in mice caused osteopenia due to enhanced osteoclast resorption secondary to the autonomous release of cathepsin K (one of the major enzymes in the degradation of bone matrix)6. This evidence concerns the gene KCNMA1 and Osteopenia.