Mechanistically, we elucidated that SNHG14/miR-5590-3p/ZEB formed a positive feedback loop in DLBCL cells to activate PD-L1, leading to the inactivation of CD8+ T cells and contributing to the immune evasion of DLBCL cells (Fig. 8). The gene discussed is ZEB1; the disease is diffuse large B-cell lymphoma.