CFTR and lung disorder: Acute and chronic cigarette smoke exposures rapidly inhibit CFTR function in smokers and in vitro.124, 125, 126 Similarly, e-cigarettes can also inhibit CFTR mediated Cl– secretion and induce airway dehydration in airway epithelia.113 Failure of ciliary beating induced by e-cigarette aerosol could conflate this, contributing to a retention of mucus and bacteria, increasing the chance of developing lung disease (table 2).