HLA-DRB1 and major depressive disorder: Three HLA alleles had evidence for association with depression after correcting for multiple testing (p < .004): HLA-B*08:01 and HLA-DQB1*02:01 (SLE) and HLA-DRB1*03:01 (multiple sclerosis, primary adrenocortical insufficiency, SLE) (Table 2).