However, while caspase-8-mediated inflammation can be triggered by the Fas-receptor [55, 74], TRAIL receptor [75], and Toll-like receptors (TLRs) [76, 77], we demonstrate herein that specifically blocking Fas activation in the microbead-induced mouse model of glaucoma inhibits the induction of caspase-8, retinal microglia activation, and the induction of proinflammatory genes, indicating the TRAIL- and TLR-mediated pathways are downstream of the FasL-Fas pathway. The gene discussed is TNFSF10; the disease is glaucoma.