Using the microbead-induced mouse model of glaucoma, we also show an induction of genes associated with each of these pathways at 4 weeks post-microbead injection, specifically C3 and C1Q (complement cascade), TLR4 (Toll-like receptor pathway), TNFα (TNFα pathway), and NLRP3 (inflammasome pathway). Here, TLR4 is linked to glaucoma.