They defined a suggestive clinical history if cutaneous signs (eczema, rash, urticaria, angioedema), gastrointestinal signs (nausea, vomiting, diarrhea, abdominal pain), respiratory signs (rhino conjunctivitis, cough, respiratory distress, bronchospasm), and/or arterial hypotension occur shortly after ingesting the food (and positive IgE test results). This evidence concerns the gene IGHE and urticaria.