IGHE and angioedema: Some conditions may point to IgE-mediated allergic reactions such as signs of skin involvement (urticaria, angioedema, erythematous rash), respiratory features (rhino conjunctivitis, cough, dyspnea, or asthma) or gastrointestinal ones (oral itching, nausea, vomit, abdominal pain, and diarrhea), or even malaise and hypotension that occur within 2 h after ingestion of a probable allergen.