IGFBP3 and hyperinsulinism: The consumption of prebiotics and dietary fibers have been associated with a decrease in markers of hyperinsulinemia and insulin resistance as well as with a favorable increase in IGF Binding Protein-3 (IGFBP-3), the latter of which is understood to quench bioavailable IGF-1 in the serum, thus mitigating tumor progression [6,7,35,36,37,38].