KIR3DL1 and acute myeloid leukemia: A seminal study in T cell depleted haploidentical transplants in AML showed that patients lacking KIR ligands (HLA-I alleles) present in haploidentical donors (“missing self”) experienced reduced risk of leukemia relapse (75% vs. 0% at 5 years), did not cause GvHD and increased overall survival [54,55].