HAVCR2 and B-cell chronic lymphocytic leukemia: NK cells with reduced cytotoxicity and lower expression of NKp46, NKp30, and CD160 have also been observed in Burkitt lymphoma and CLL [40]; while increased expression of the T-cell immunoglobulin and mucin domain-3 (TIM-3) inhibitory receptor on NK cells correlates with a poor prognosis in CLL [35].