As a tumor is often described as being like a “chronic wound” [78,79,80], the hypoxic conditions and high concentration of cytokines and growth factors IL-1α, IL-1β, IL-6, FGF-2, IGF-1, TGF-β, VEGF-A, HIF-1α, EGF, TGF-α are a likely trigger for MSCs recruitment to tumor microenvironments [79,81,82]. This evidence concerns the gene IGF1 and neoplasm.