Based on cytogenetic abnormalities, MM can originate from two pathways: the hyperdiploidy of chromosomes 3, 5, 7, 9, 11, 15, 19 and 21, which is observed in 55% of patients; the translocation of IGH or MYC, observed in 40% to 50% of patients [4]. Here, MYC is linked to Miyoshi myopathy.